Source data must be in columns as: [Distance] [Difference] (each case expressing distances in a pair of sites parsed in a separate row, column separator can be either space, tab or semicolon, decimal separator can be either point or comma). Lines beginning with a character (column headers) are excluded.

Values in the first column are treated as distances, values in the second column as similarity or dissimilarity. Values in the second column are permutated to find confidence limits and statistical significance for the Mantel statistic (rM). The Mantel statistic is calculated as the linear correlation between values in the first and second column.